Cell cycle control of Wnt/b-catenin signalling by conductin/axin2 through CDC20
نویسندگان
چکیده
Wnt/b-catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/ axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/b-catenin target genes are low at G2/M and high at G1/S, and b-catenin phosphorylation oscillates during the cell cycle in a conductindependent manner. Conductin is degraded by the anaphasepromoting complex/cyclosome cofactor CDC20. Knockdown of CDC20 blocks Wnt signalling through conductin. CDC20resistant conductin inhibits Wnt signalling and attenuates colony formation of colorectal cancer cells. We propose that CDC20mediated degradation of conductin regulates Wnt/b-catenin signalling for maximal activity during G1/S.
منابع مشابه
Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20.
Wnt/β-catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/β-catenin target genes are low at G2/M and high at G1/S, and β-catenin phosphorylation oscillates during the cell cycle in a conductin-dependent m...
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